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About RheumaScore
The most comprehensive encrypted clinical score calculator for rheumatology
Overview
What is RheumaScore?
RheumaScore is a clinical decision-support platform built for rheumatologists. It computes 32 validated disease activity, damage, quality of life, and cardiovascular risk scores — all using Fully Homomorphic Encryption (FHE), meaning patient data is never exposed to the server.
Built by LESAI, the AI rheumatologist powering Decentralized Science (DeSci) in rheumatology. Every computation happens on encrypted data — the server processes ciphertext and returns encrypted results that only your browser can decrypt.
Encryption
How FHE Works
Fully Homomorphic Encryption allows mathematical operations on encrypted data without ever decrypting it. Your clinical values never leave your browser in plaintext.
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Encrypt
Data encrypted in your browser before leaving the device
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Compute
Server performs calculations on ciphertext — never sees your data
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Decrypt
Encrypted result sent back and decrypted only in your browser
Powered by Zama Concrete — a Python FHE compiler for privacy-preserving computation
Clinical Scores
32 Validated Scores
Organized across four categories covering disease activity, organ damage, patient-reported outcomes, and cardiovascular risk.
Lupus (SLE)
SLEDAI-2KSDIBILAG-2004PGA
Rheumatoid Arthritis
SDAIDAS28-CRP
Spondyloarthritis
BASDAIASDAS-CRP
Systemic Sclerosis
mRSSDETECT
Psoriasis / PsA
PASIDAPSA
Antiphospholipid Syndrome
GAPSS
mSCORE-EULAR
With 1.5× rheumatic disease multiplier
CHA₂DS₂-VASc
Stroke risk in AF — common in RA/SLE
Reynolds Risk Score
Includes hsCRP for inflammatory context
Patient-Reported Outcomes
EQ-5D-5LHAQ-DIFACIT-FatiguePHQ-9DLQIASQoLRAPID3
Pediatric Scores
JADAS-27cJADAS-10CHAQWallace CriteriaJSPADACMASPVAS
Tools
PDF Lab Report Analyzer
Upload laboratory reports in PDF format and automatically extract clinical values — entirely in your browser.
📄 How it works
- Upload lab reports (PDF) and auto-extract clinical values
- Supports Spanish and English lab report formats
- Detects 30+ clinical parameters — ESR, CRP, complement, autoantibodies, CBC, metabolic panels, and more
- Auto-computes all applicable scores from extracted data
- PDF is processed 100% in the browser — never uploaded to any server
Coming Soon
Patient Vault Coming Soon
Encrypted longitudinal patient tracking with zero-knowledge architecture.
🔐 Zero-Knowledge Patient Records
- Login with crypto wallet (Phantom / MetaMask)
- All data encrypted with doctor's personal PIN using AES-256-GCM
- Server stores only encrypted blobs — zero-knowledge architecture
- Track score evolution over time with interactive charts
- Complete compliance: HIPAA, GDPR, LFPDPPP, ICH-GCP
Trust
Privacy & Compliance
RheumaScore is built on a zero-knowledge architecture. Even if the server were compromised, patient data would be meaningless — only encrypted blobs exist server-side.
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HIPAA § 164.312
Technical safeguards — encryption standard for ePHI
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GDPR Art. 32
Encryption at rest & in transit
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LFPDPPP Art. 9
Sensitive health data protection
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ICH-GCP
Good Clinical Practice guidelines
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Declaration of Helsinki
Ethical principles for medical research
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No Tracking
No cookies, no analytics, no third-party scripts
Engineering
Technology Stack
Frontend
Vanilla JS · Chart.js
Encryption
Web Crypto API
Infrastructure
Cloudflare
Client-side encryption: AES-256-GCM + PBKDF2 via Web Crypto API · Payments: Solana Pay ($LES_AI), ETH (Base & Mainnet) · CDN & DDoS: Cloudflare
The AI Behind It
About LESAI
LESAI is an AI rheumatologist specializing in systemic lupus erythematosus (SLE) and autoimmune diseases, operating within the Decentralized Science (DeSci) ecosystem.
Team
Credits
🧬 Built by
- LESAI — AI rheumatologist & clinical engine
- DNAI (Distributed Neural Artificial Intelligence) — Root scientific and ethical AI agent of the DeSci ecosystem
- CryptoReuMd.eth — Medical oversight
- FHE powered by Zama